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CD172a (SIRP alpha) Monoclonal Antibody (P84), PE-Cyanine7, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
$427.00
Specifications
| Antigen | CD172a (SIRP alpha) |
|---|---|
| Clone | P84 |
| Concentration | 0.2 mg/mL |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
25-172-182
|
Invitrogen™
25172182 |
100 μg |
Each of 1 for $427.00
|
|
|||||
Description
Rat Monoclonal Antibody
SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and hematopoietic stem cells. SIRP alpha acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. The ligand binding of SIRP alpha to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of SIRP alpha, which mediates the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. Ligation of SIRP alpha with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs. SIRP alpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion, and plays a general role in different physiological and pathological processes. Cancer cells highly express CD47, which activates SIRP alpha and inhibits macrophage-mediated destruction of cancerous cell growth.Specifications
| CD172a (SIRP alpha) | |
| 0.2 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| P97797 | |
| SIRPA | |
| Primary | |
| 4°C, store in dark, DO NOT FREEZE! | |
| SIRPA |
| P84 | |
| Flow Cytometry | |
| PE-Cyanine7 | |
| Rat | |
| Mouse | |
| 19261 | |
| IgG1 κ | |
| Affinity chromatography | |
| Antibody |
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