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Invitrogen™ CD180 Monoclonal Antibody (MHR73), Biotin

Catalog No. PIMA134128
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250 μL
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Catalog No. Quantity
PIMA134128 250 μL
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Catalog No. PIMA134128 Supplier Invitrogen™ Supplier No. MA134128

Description

Mouse Monoclonal Antibody

MA1-34128 detects RP105 from human samples.

CD180 (RP105, Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. CD180 cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1, and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size. CD180 consists of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is part of the cell surface receptor complex, RP105/MD-1. Diseases associated with CD180 dysfunction include Kawasaki Disease in children and may play a role in rheumatic disease pathology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD180
Applications Flow Cytometry, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone MHR73
Concentration 0.1 mg/mL
Conjugate Biotin
Formulation PBS with 0.1% BSA and 0.02% sodium azide
Gene Cd180
Gene Accession No. Q99467
Gene Alias CD180; CD180 antigen; CD180 molecule; F630107B15; LY64; Ly78; Ly-78; lymphocyte antigen 64; Lymphocyte antigen 78; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; radioprotective 105 kDa protein; RP105
Gene Symbols Cd180
Host Species Mouse
Immunogen Proprietary.
Purification Method Purified
Quantity 250 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4064
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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