CD183 (CXCR3) Mouse, anti-Mouse, R718, Clone: CXCR3-173, BD OptiBuild™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 752155

Catalog No. BDB752155

Description

The CXCR3-173 monoclonal antibody specifically binds to mouse CD183, also known as CXCR3. CD183 is a seven transmembrane spanning, G protein-coupled chemokine receptor for CXC chemokines including CXCL9 (Mig), CXCL10 (IP-10) and CXCL11 (I-TAC). These chemokines are induced by inflammatory cytokines including IFN-γ, IFN-α/β, and TNF. CXCR3 is primarily expressed on activated/memory CD4+ and CD8+ T lymphocytes, Foxp+ regulatory T cells, natural killer T (NKT) cells and mature NK cells. Binding of chemokines to CXCR3 induces integrin activation, cytoskeletal changes, and chemotactic migration of activated lymphocytes. CD183 has been reported to play important roles in T cell recruitment and immune responses in a number of inflammatory and autoimmune diseases. The CXCR3-173 antibody reportedly inhibited in vitro chemotactic responses to CXCL10 or CXCL11 significantly but not to CXCL9. When administered systemically to mouse hosts, the CXCR3-173 antibody reportedly prolonged cardiac and pancreatic islet cell allograft survival. In the presence of CXCR3 ligands, especially, CXCL10 and CXCL11, staining with the antibody can be significantly blocked.

Specifications

• Antigen: CD183 (CXCR3)
• Classification: Monoclonal
• Conjugate: R718
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Refrigerate Upon Arrival

• Applications: Flow Cytometry
• Clone: CXCR3-173
• Host Species: Mouse
• Regulatory Status: RUO
• Target Species: Mouse
• Form: Liquid