CD185 (CXCR5) Monoclonal Antibody (MU5UBEE), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  LIFE TECHNOLOGIES 14918537

Catalog No. 14-918-537

Description

The MU5UBEE MAb reacts with Human CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt's lymphoma. In peripheral blood, CXCR5 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), as well as on a subpopulation of memory (CD45RO+) T cells. CXCR5+ circulating T cells are in a resting state and migrate to the lymph nodes due to expression of CCR7 and CD62L. In tonsil, CXCR5 is expressed on nearly all CD4+ cells along with CD45RO and such activation markers as CD69 and ICOS. Tonsillar CXCR5+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing B cell help. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follicles of germinal centers in response to CXCL13, making CXCR5 an established marker of follicular helper T cells.

CD185 (CXCR5) Monoclonal antibody specifically detects CD185 (CXCR5) in Human, Non-human Primate, Rhesus Monkey samples. It is validated for Flow Cytometry

Specifications

• Antigen: CD185 (CXCR5)
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: P32302
• Host Species: Mouse
• Quantity: 2 mg
• Primary or Secondary: Primary
• Target Species: Human, Non-human Primate, Rhesus Monkey
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: Flow Cytometry
• Clone: MU5UBEE
• Conjugate: Unconjugated
• Gene: CXCR5
• Gene Alias: Blr1; Blr-1; Burkitt lymphoma receptor 1; burkitt lymphoma receptor 1 homolog; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD185; CD185 antigen; chemochine (C-X-C motif) receptor 5; chemokine (C-X-C motif) receptor 5; CXC; C-X-C chemokine receptor type 5; CXC motif chemokine; C-X-C motif chemokine receptor 5; CXCR5; CXC-R5; CXCR-5; EGK_06966; Fusin; Gpcr6; GPR9; HUMSTR; LESTR; MDR15; MDR-15; monocyte-derived receptor 15; Neurolymphatic receptor; NLR
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 643, 701792
• Content And Storage: 4° C
• Form: Liquid