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CD19 Mouse anti-Human, Qdot® 605, Clone: SJ25-C1, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen Q10306

Catalog No. 50-113-8152


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Description

Description

CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains. CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and maligt B cell proliferation, and is expressed in all B cell precursor leukemias. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Specifications

Specifications

CD19
Monoclonal
Qdot® 605
CD19
Liquid
CD19
Nalm 1 human cell line.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
SJ25-C1
0.05M borate with 1M betaine and 0.05% sodium azide; pH 8.3
P15391
AW495831, B-lymphocyte antigen CD19, differentiation antigen CD19
Mouse
IgG1, kappa
100 μL
4° C
Primary
930
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