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  6. BD Horizon™ CD19 Mouse, anti-Human, RY586, Clone: SJ25C1, BD Horizon™

BD Horizon™ CD19 Mouse, anti-Human, RY586, Clone: SJ25C1, BD Horizon™

Catalog No. BDB568107 Shop All BD Biosciences Products
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Catalog No. BDB568107 Supplier BD Horizon™ Supplier No. 568107
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Description

Mouse Monoclonal Antibody

The SJ25C1 monoclonal antibody specifically binds to CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 90-kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to play a role in complement-mediated mast-cell activation.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD19
Applications Flow Cytometry
Clone SJ25C1
Conjugate RY586
Host Species Mouse
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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