MilliporeSigma™ CD19, Mouse, APC, Clone: SJ25C1,
Mouse Monoclonal Antibody
Manufacturer: MilliporeSigma™ MABF1644
DescriptionThe SJ25C1 antibody reacts with human CD19, a 95kDa glycoprotein which acts as a co-receptor, along with CD21 (CR2), CD81 (TAPA-1) and CD225 (Leu13), in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. Upon activation and tyrosine phosphorylation, the CD19 molecule can provide an anchor for cytoplasmic signaling proteins such as GRB2, SOS or PLCG2. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells.
|Please refer to lot specific datasheet.|
|Purified mouse monoclonal in buffer containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.|
|Immunogen information for this antibody is proprietary information.|
|Inflammation & Immunology|
|Purified by size-exclusion chromatography|
Safety and Handling
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For Research Use Only. Not for use in diagnostic procedures.