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CD195 Rat anti-Mouse, Brilliant Violet 421, Clone: C34-3448, BD Optibuild™

Catalog No. BDB743695 Shop All BD Biosciences Products
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BDB743695 50 μg
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Catalog No. BDB743695 Supplier BD Biosciences Supplier No. 743695
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Description

Rat Monoclonal Antibody

The C34-3448 monoclonal antibody specifically binds to CD195 which is also known as, C-C chemokine receptor type 5 (CCR5). CD195 is a seven transmembrane-spanning G-protein-coupled receptor that belongs to chemokine receptor family. CD195 regulates lymphocyte chemotaxis activation and transendothelial migration during inflammation. It signals in response to at least three chemokines: CCL3/MIP-1α, CCL4/MIP-1 β, and CCL5/RANTES. CD195 is expressed on macrophages and some T-lymphocytes.

The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407nm and Em Max at 421nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates. BV421 is a polymer-based dye excited by the violet laser and is one of the brightest fluorochromes offered by BD Biosciences. Conjugates are typically 10 times brighter than Pacific Blue™ conjugates and are often as bright as or brighter than PE conjugates. Due to nearly identical excitation and emission properties but different spillover characteristics, BD Horizon BV421, Pacific Blue™, and BD Horizon™ V450 cannot be used simultaneously.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD195
Classification Monoclonal
Clone C34-3448
Concentration 0.2mg/mL
Conjugate Brilliant Violet 421
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Ccr5, chemokine (C-C) receptor 5, C-C CKR-5, CC-CKR-5, CCR-5, AM4-7
Host Species Rat
Immunogen Mouse CCR5 aa. 9-30
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2c κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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