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CD195 Rat anti-Mouse, Brilliant Violet 711, Clone: C34-3448, BD Optibuild™

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BDB743699 50 μg
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Catalog No. BDB743699 Supplier BD Biosciences Supplier No. 743699
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Description

Rat Monoclonal Antibody

The C34-3448 monoclonal antibody specifically binds to CD195 which is also known as, C-C chemokine receptor type 5 (CCR5). CD195 is a seven transmembrane-spanning G-protein-coupled receptor that belongs to chemokine receptor family. CD195 regulates lymphocyte chemotaxis activation and transendothelial migration during inflammation. It signals in response to at least three chemokines: CCL3/MIP-1α, CCL4/MIP-1 β, and CCL5/RANTES. CD195 is expressed on macrophages and some T-lymphocytes.

The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 711nm. BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20nm filter). Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors. However, the spillover can be corrected through compensation as with any other dye combination. BV711 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 711 nm. This dye offers a very bright choice for the violet laser. Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors. BV711 will also have moderate spillover into the BD Horizon Brilliant™ Violet 786 detector.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD195
Classification Monoclonal
Clone C34-3448
Concentration 0.2mg/mL
Conjugate Brilliant Violet 711
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Ccr5, chemokine (C-C) receptor 5, C-C CKR-5, CC-CKR-5, CCR-5, AM4-7
Host Species Rat
Immunogen Mouse CCR5 aa. 9-30
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2c κ
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