Invitrogen™ CD1a Monoclonal Antibody (CBT6)

Catalog No.	Quantity
01-676-957	100 μg

Catalog No. 01-676-957 Supplier Invitrogen™ Supplier No. MA135117

Description

Mouse Monoclonal Antibody

CB-T6 specifically reacts with CD1a, an MHC like transmembrane glycoprotein of 49 kDa, that presents lipid molecules and is non-covalently associated with beta2-microglobulin. The antigen is strongly expressed on cortical thymocytes and dendritic cells and disappears at later stages of maturation.

CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta 2 microglobulin. CD1a is expressed by cortical thymocytes, Langerhan's cells and by interdigitating cells. CD1a is also expressed by some malignancies of T cell lineage and in histiocytosis X. CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1a is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1a localizes to the plasma membrane and recycles vesicles of the early endocytic system. At least five CD1 genes (CD1a, b, c, d, and e) are identified. Alternatively spliced transcript variants of CD1a have been observed, but their biological validity have not been determined.

Specifications

• Antigen: CD1a
• Applications: Immunohistochemistry (Frozen)
• Classification: Monoclonal
• Clone: CBT6
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: CD1A
• Gene Accession No.: P06126
• Gene Alias: CD1; CD1 antigen; CD1.1; CD1A; CD1A antigen, a polypeptide; CD1a molecule; cd1a1; CD1A1 antigen; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; FCB6; HTA1; hTa1 thymocyte antigen; R4; T6; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a
• Gene Symbols: Cd1, CD1A
• Host Species: Mouse
• Immunogen: Jurkat cells.
• Purification Method: Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 111334, 909
• Target Species: Human, Mouse
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1