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Invitrogen™ CD1a Monoclonal Antibody (MTB1)
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Catalog No. PIMA514096
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500 μL
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Catalog No. Quantity
PIMA514096 500 μL
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Catalog No. PIMA514096 Supplier Invitrogen™ Supplier No. MA514096
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Description

Mouse Monoclonal Antibody

MA5-14096 targets CD1a in IHC (P) applications and shows reactivity with Human samples. The MA5-14096 immunogen is full external domain of CD1a.

CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta 2 microglobulin. CD1a is expressed by cortical thymocytes, Langerhan's cells and by interdigitating cells. CD1a is also expressed by some malignancies of T cell lineage and in histiocytosis X. CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1a is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1a localizes to the plasma membrane and recycles vesicles of the early endocytic system. At least five CD1 genes (CD1a, b, c, d, and e) are identified. Alternatively spliced transcript variants of CD1a have been observed, but their biological validity have not been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD1a
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone MTB1
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Tissue culture supernatant with 0.09% sodium azide
Gene CD1A
Gene Accession No. P06126
Gene Alias CD1; CD1 antigen; CD1.1; CD1A; CD1A antigen, a polypeptide; CD1a molecule; cd1a1; CD1A1 antigen; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; FCB6; HTA1; hTa1 thymocyte antigen; R4; T6; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a
Gene Symbols CD1A
Host Species Mouse
Immunogen Full external domain of CD1a.
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 909
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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