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Invitrogen™ CD1a Monoclonal Antibody (O10)
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Catalog No. PIMA512526
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500 μL
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PIMA512526 500 μL
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Catalog No. PIMA512526 Supplier Invitrogen™ Supplier No. MA512526
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Description

Mouse Monoclonal Antibody

This antibody detects CD1a in mouse and human samples in FACS, WB and IHC (P) applications.

CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta 2 microglobulin. CD1a is expressed by cortical thymocytes, Langerhan's cells and by interdigitating cells. CD1a is also expressed by some malignancies of T cell lineage and in histiocytosis X. CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1a is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1a localizes to the plasma membrane and recycles vesicles of the early endocytic system. At least five CD1 genes (CD1a, b, c, d, and e) are identified. Alternatively spliced transcript variants of CD1a have been observed, but their biological validity have not been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD1a
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone O10
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene CD1A
Gene Accession No. P06126
Gene Alias CD1; CD1 antigen; CD1.1; CD1A; CD1A antigen, a polypeptide; CD1a molecule; cd1a1; CD1A1 antigen; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; FCB6; HTA1; hTa1 thymocyte antigen; R4; T6; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a
Gene Symbols Cd1, CD1A
Host Species Mouse
Immunogen Human thymus cells.
Purification Method Protein A/G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 111334, 909
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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