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Invitrogen™ CD1a Polyclonal Antibody
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Catalog No. PIPA582406
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100 μL
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PIPA582406 100 μL
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Catalog No. PIPA582406 Supplier Invitrogen™ Supplier No. PA582406
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QNLVSGWLSD LQTHTWDSNS STIVFLCPWS RGNFSNEEWK ELETLFRIRT IRSFEGIRRY AHELQFEYPF EIQVTGGCEL HSGKVSGSFL QLAYQGSDFV SFQNNSWLPY PVAGNMAKHF CKVLNQNQHE ND Highest antigen sequence indentity to the following orthologs: Mouse - 37%, Rat - 35%.

CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta 2 microglobulin. CD1a is expressed by cortical thymocytes, Langerhan's cells and by interdigitating cells. CD1a is also expressed by some malignancies of T cell lineage and in histiocytosis X. CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1a is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1a localizes to the plasma membrane and recycles vesicles of the early endocytic system. At least five CD1 genes (CD1a, b, c, d, and e) are identified. Alternatively spliced transcript variants of CD1a have been observed, but their biological validity have not been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD1a
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CD1A
Gene Accession No. P06126
Gene Alias CD1; CD1 antigen; CD1.1; CD1A; CD1A antigen, a polypeptide; CD1a molecule; cd1a1; CD1A1 antigen; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; FCB6; HTA1; hTa1 thymocyte antigen; R4; T6; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a
Gene Symbols CD1A
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CD1A. Recombinant protein control fragment (Product #RP-90349).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 909
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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