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  6. Invitrogen™ CD1c Monoclonal Antibody (L161), NovaFluor™ Blue 690, eBioscience™, Invitrogen™ 

Invitrogen™ CD1c Monoclonal Antibody (L161), NovaFluor™ Blue 690, eBioscience™, Invitrogen™

Catalog No. H046T03B09A
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H046T03B09A 100 Tests
H046T02B09A 25 Tests
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Description

Mouse Monoclonal Antibody

CD1c is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. This family of proteins is involved in the presentation of lipid and glycolipid antigens, both of self and microbial origin, to T cells during the adaptive immune response. CD1c is expressed on some circulating and marginal zone B cells, as well as in lymph nodes and germinal centers. It plays a crucial role in presenting lipid antigens, such as microbial fatty acids, to effector T cells. The protein encoded by the CD1c gene localizes to late endosomes and lysosomes, utilizing a tyrosine-based motif in its cytoplasmic tail for targeting. Vesicular acidification is required for CD1c to bind lipid antigens effectively. The human genome contains five CD1 family genes organized in a cluster on chromosome 1, with each member differing in cellular localization and specificity for particular lipid ligands. CD1c undergoes alternative splicing, resulting in three different isoforms: soluble, membrane-bound, and cytoplasmic/soluble isoforms, highlighting its functional diversity in immune processes.
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Specifications

Antigen CD1c
Applications Flow Cytometry
Classification Monoclonal
Clone L161
Concentration 0.2 μg/Test
Conjugate NovaFluor Blue 690
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene CD1C
Gene Accession No. P29017
Gene Alias BDCA1; canCD1c; CD1; CD1A; CD1C; CD1C antigen, c polypeptide; CD1c molecule; cortical thymocyte antigen CD1C; differentiation antigen CD1-alpha-3; R7; RP11-101J8.3; T-cell surface glycoprotein CD1c
Gene Symbols CD1C
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 911
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG1 κ
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