CD1d Mouse, anti-Rat, R718, Clone: WTH1, BD OptiBuild™
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 752190
The WTH1 monoclonal antibody specifically binds to rat CD1d and crossreacts with mouse CD1d (with stronger reactivity against mouse CD1d1 than CD1d2). CD1d is a type I transmembrane glycoprotein that is noncovalently associated with β2-microglobulin. CD1d is expressed on various cell types including subsets of thymocytes, T cells, B cells, monocytes, macrophages, dendritic cells, endothelial cells and epithelial cells. Although structurally similar to MHC Class I antigens, CD1d molecules are rather non-polymorphic and serve to present non-peptide antigens such as endogenous or microbial glycolipids to T lymphocytes (NKT cells). The WTH2 monoclonal antibody reportedly binds to a non-overlapping epitope on rat CD1d and also crossreacts with mouse CD1d when compared with WTH1. Both WTH1 and WTH2 reportedly interfere with antigen recognition by CD1d-restricted T cells.
|Refrigerate Upon Arrival|
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