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Invitrogen™ CD200 Monoclonal Antibody (MRC OX104), FITC
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Catalog No. 01672421
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100 μg
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Catalog No. Quantity
01672421 100 μg
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Catalog No. 01672421 Supplier Invitrogen™ Supplier No. MA135930
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Description

Mouse Monoclonal Antibody

OX-104 recognizes the human CD200 cell surface antigen, also known as OX2.CD200 is expressed by a subset of B lymphocytes, some endothelial cells and by neurons. Studies have suggested that the CD200-CD200 ligand system is of importance in the control of macrophage and granulocyte activation.

CD200 is a type-1 membrane glycoprotein in the immunoglobulin superfamily, featuring two immunoglobulin domains. It is widely expressed on various cells, including B and T cells, keratinocytes, nerve cells, follicular dendritic cells, ovarian cells, and trophoblasts. CD200 interacts with CD200R on myeloid cells, inhibiting macrophage activation, reducing IL-6 production, and attenuating lymphocyte activation. It also prevents mast cell degranulation and decreases TNF-alpha and IL-13 secretion, playing a role in immune regulation and maternal tolerance. Homologues of CD200 are found in herpesviruses and poxviruses, indicating a conserved immune modulation function. CD200 has multiple alternatively spliced transcript variants, contributing to its functional diversity. Diseases linked to CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy, highlighting its importance in health and disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD200
Applications Flow Cytometry
Classification Monoclonal
Clone MRC OX104
Concentration 0.1 mg/mL
Conjugate FITC
Formulation PBS with 1% BSA and 0.09% sodium azide
Gene Cd200
Gene Accession No. P41217
Gene Alias antigen identified by monoclonal antibody MRC OX-2; CD200; Cd200 antigen; Cd200 molecule; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2); Cspmo2; hypothetical protein LOC534910; MOX1; MOX2; MRC; MRC OX-2 antigen; MRCOX2; My033; OX2; OX-2; OX-2 membrane glycoprotein
Gene Symbols Cd200
Host Species Mouse
Immunogen Proprietary immunogen.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4345
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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