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Invitrogen™ CD200 Monoclonal Antibody (MRC OX104), FITC
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA135930
Description
OX-104 recognizes the human CD200 cell surface antigen, also known as OX2.CD200 is expressed by a subset of B lymphocytes, some endothelial cells and by neurons. Studies have suggested that the CD200-CD200 ligand system is of importance in the control of macrophage and granulocyte activation.
CD200 is a type-1 membrane glycoprotein that contains two immunoglobulin domains, and belongs to the immunoglobulin superfamily. CD200 is a broadly distributed cell surface glycoprotein that interacts with a receptor on myeloid cells (CD200R) and is implicated in locally preventing macrophage activation. Distant, but recognizable, homologues of CD200 have been identified in many herpesviruses and poxviruses. Studies of the related genes in mouse and rat suggest that CD200 may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms of CD200 have been found. Diseases associated with CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy.
Specifications
CD200 | |
Monoclonal | |
0.1 mg/mL | |
PBS with 1% BSA and 0.09% sodium azide | |
P41217 | |
Cd200 | |
Proprietary immunogen. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
Flow Cytometry | |
MRC OX104 | |
FITC | |
Cd200 | |
antigen identified by monoclonal antibody MRC OX-2; CD200; Cd200 antigen; Cd200 molecule; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2); Cspmo2; hypothetical protein LOC534910; MOX1; MOX2; MRC; MRC OX-2 antigen; MRCOX2; My033; OX2; OX-2; OX-2 membrane glycoprotein | |
Mouse | |
Purified | |
RUO | |
4345 | |
4°C, store in dark | |
Liquid |
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