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Invitrogen™ CD200 Polyclonal Antibody
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Catalog No. PIPA545463
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PIPA545463 100 μL
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Catalog No. PIPA545463 Supplier Invitrogen™ Supplier No. PA545463
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Description

Rabbit Polyclonal Antibody

Peptide sequence: PRSGIENSTV TLSHPNGTTS VTSILHIKDP KNQVGKEVIC QVLHLGTVTD Sequence homology: Cow: 79%; Dog: 79%; Guinea Pig: 79%; Human: 100%; Mouse: 79%; Pig: 86%; Rabbit: 79%; Rat: 79%.

CD200 is a type-1 membrane glycoprotein in the immunoglobulin superfamily, featuring two immunoglobulin domains. It is widely expressed on various cells, including B and T cells, keratinocytes, nerve cells, follicular dendritic cells, ovarian cells, and trophoblasts. CD200 interacts with CD200R on myeloid cells, inhibiting macrophage activation, reducing IL-6 production, and attenuating lymphocyte activation. It also prevents mast cell degranulation and decreases TNF-alpha and IL-13 secretion, playing a role in immune regulation and maternal tolerance. Homologues of CD200 are found in herpesviruses and poxviruses, indicating a conserved immune modulation function. CD200 has multiple alternatively spliced transcript variants, contributing to its functional diversity. Diseases linked to CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy, highlighting its importance in health and disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD200
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene Cd200
Gene Accession No. P41217
Gene Alias antigen identified by monoclonal antibody MRC OX-2; CD200; Cd200 antigen; Cd200 molecule; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2); Cspmo2; hypothetical protein LOC534910; MOX1; MOX2; MRC; MRC OX-2 antigen; MRCOX2; My033; OX2; OX-2; OX-2 membrane glycoprotein
Gene Symbols Cd200
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal of human CD200 (aa 175-224).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4345
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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