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CD200 Receptor Monoclonal Antibody (OX110), PE, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

$127.00 - $279.00

Specifications

Antigen CD200 Receptor
Clone OX110
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-108-13
Encompass_Preferred
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Invitrogen™
12520180
25 μg
Each for $127.00
Only null left
Add to Cart
 
50-108-14
Encompass_Preferred
View Documents
Invitrogen™
12520182
100 μg
Each for $279.00
Only null left
Add to Cart
 
Description

Description

Description: The monoclonal antibody OX110 recognizes mouse CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNF alpha secretion. Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells. Applications Reported: This OX110 antibody has been reported for use in flow cytometric analysis. Applications Tested: This OX110 antibody has been tested by flow cytometric analysis of mouse thioglycolate-elicited peritoneal exudate cells. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered.

CD200R (OX2R) is a receptor for the OX-2 membrane glycoprotein, and both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. CD200R is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. In mouse, CD200R is expressed primarily by peripheral blood monocytes and neutophils but also by other leucocytes including T-lymphocytes and mast cells. Further mouse studies of a gene related to CD200R suggests that the receptor may control myeloid function in a tissue-specific manner. Alternative splicing of CD200R results in multiple transcript variants. Diseases associated with CD200R dysfunction include primary hypertrophic osteoarthropathy.
Specifications

Specifications

CD200 Receptor
0.2 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
antigen identified by monoclonal antibody MRC OX-2 receptor; CD200 cell surface glycoprotein receptor; CD200 R1; CD200 receptor 1; CD200R; Cd200r1; Cell surface glycoprotein CD200 receptor 1; cell surface glycoprotein OX2 receptor 1; cell surface glycoprotein receptor CD200; CRTR2; HCRTR2; MOX2 receptor; MOX2R; Orexin receptor 2; OX102 antigen; OX2 receptor; OX2R; UNQ2522/PRO6015
CD200R1
Primary
4°C, store in dark, DO NOT FREEZE!
CD200R1
OX110
Flow Cytometry
PE
Rat
Mouse
Q9ES57
57781
IgG2a κ
Affinity Chromatography
Antibody
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