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Invitrogen™ CD200 Recombinant Rabbit Monoclonal Antibody (002), APC
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Catalog No. PIMA546780
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100 Tests
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PIMA546780 100 Tests
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Catalog No. PIMA546780 Supplier Invitrogen™ Supplier No. MA546780
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Description

Rabbit Recombinant Monoclonal Antibody

Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD200 (Met1-Gly232) and conjugated with APC under optimum conditions, the unreacted APC was removed. Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

CD200 is a type-1 membrane glycoprotein in the immunoglobulin superfamily, featuring two immunoglobulin domains. It is widely expressed on various cells, including B and T cells, keratinocytes, nerve cells, follicular dendritic cells, ovarian cells, and trophoblasts. CD200 interacts with CD200R on myeloid cells, inhibiting macrophage activation, reducing IL-6 production, and attenuating lymphocyte activation. It also prevents mast cell degranulation and decreases TNF-alpha and IL-13 secretion, playing a role in immune regulation and maternal tolerance. Homologues of CD200 are found in herpesviruses and poxviruses, indicating a conserved immune modulation function. CD200 has multiple alternatively spliced transcript variants, contributing to its functional diversity. Diseases linked to CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy, highlighting its importance in health and disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD200
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone 002
Concentration 100 μg/mL
Conjugate APC
Formulation PBS with 0.5% BSA and 0.09% sodium azide
Gene Cd200
Gene Accession No. O54901
Gene Alias antigen identified by monoclonal antibody MRC OX-2; CD200; Cd200 antigen; Cd200 molecule; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2); Cspmo2; hypothetical protein LOC534910; MOX1; MOX2; MRC; MRC OX-2 antigen; MRCOX2; My033; OX2; OX-2; OX-2 membrane glycoprotein
Gene Symbols Cd200
Host Species Rabbit
Immunogen Recombinant protein encoding Mouse CD200 (Met1-Gly232).
Purification Method Protein A
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17470
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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