Invitrogen™ CD200R Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596991

Catalog No. PIPA596991

Description

Immunogen sequence: SLYIELLPVP GAKKSAKLYI PYIILTIIIL TIVGFIWLLK VNGCRKYKLN KTESTPVVEE DEMQPYASYT EKNNPLYDTT NKVKASEALQ SEVDTDLHTL; Positive Samples: U-937, NCI-H460; Cellular Location: Cell membrane, Single-pass type I membrane protein, Single-pass type I membrane protein.

CD200R (OX2R) is a receptor for the OX-2 membrane glycoprotein, and both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. CD200R is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. In mouse, CD200R is expressed primarily by peripheral blood monocytes and neutophils but also by other leucocytes including T-lymphocytes and mast cells. Further mouse studies of a gene related to CD200R suggests that the receptor may control myeloid function in a tissue-specific manner. Alternative splicing of CD200R results in multiple transcript variants. Diseases associated with CD200R dysfunction include primary hypertrophic osteoarthropathy.

Specifications

• Antigen: CD200R
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CD200R1
• Gene Alias: antigen identified by monoclonal antibody MRC OX-2 receptor; CD200 cell surface glycoprotein receptor; CD200 R1; CD200 receptor 1; CD200R; Cd200r1; Cell surface glycoprotein CD200 receptor 1; cell surface glycoprotein OX2 receptor 1; cell surface glycoprotein receptor CD200; CRTR2; HCRTR2; MOX2 receptor; MOX2R; Orexin receptor 2; OX102 antigen; OX2 receptor; OX2R; UNQ2522/PRO6015
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 131450
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.62 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8TD46
• Gene Symbols: CD200R1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 249-348 of human CD200R1 (NP_6201611).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG