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CD202b (TIE2) Monoclonal Antibody (TEK4), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

$155.00 - $544.00

Specifications

Antigen CD202b (TIE2)
Clone TEK4
Concentration 0.5 mg/mL
Applications Flow Cytometry, Immunohistochemistry (Frozen)
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-134-12
Encompass_Preferred
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Invitrogen™
14598782
100 μg
Each for $155.00
Only null left
Edge
Add to Cart
 
50-134-13
Encompass_Preferred
View Documents
Invitrogen™
14598785
500 μg
Each for $544.00
Only null left
Add to Cart
 
Description

Description

Description: The TEK4 monoclonal antibody reacts with mouse Tie-2, also known as CD202. A member of the tyrosine kinase receptor family, Tie-2 is expressed on endothelial and a subset of hematopoietic cells and is believed to play a role in both angiogenesis and hematopoiesis during development of the mouse embryo. In fetal liver and adult bone marrow, Tie-2 is expressed by a subpopulation of hematopoietic progenitor cells characterized as Lineage markers^-, c-Kit^+, Sca1^+ cells. Long-term multilineage repopulating cells were detected in Tie-2^+, Lineage^-, c-Kit^+, Sca1^+ cells but not in Tie-2^-, Lineage^-, c-Kit^+, Sca1^+ cells. Applications Reported: This TEK4 antibody has been reported for use in flow cytometric analysis, and immunohistology staining of frozen tissue sections. Applications Tested: The TEK4 antibody has been tested by blocking of staining with fluorochrome conjugated TEK4 on mouse bone marrow cells. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
Specifications

Specifications

CD202b (TIE2)
0.5 mg/mL
Monoclonal
Liquid
RUO
Q02858
IgG1 κ
Affinity chromatography
Antibody
TEK4
Flow Cytometry, Immunohistochemistry (Frozen)
Unconjugated
Rat
Mouse
21687
Primary
4°C
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.

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