Learn More
Invitrogen™ CD204 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA589666
Description
Immunogen sequence: LNIENLNGKI QENTFKQQEE ISKLEERVYN VSAEIMAMKE EQVHLEQEIK GEVKVLNNIT NDLRLKDWEH SQTLRNITLI QGPPGPPGEK GDRGPTGESG PRGFPGPIGP PGLKGDRGAI GFPGSRGLPG YAGRPGNSGP KGQKGEKGSG NTLTPFTKVR LVGGSGPHEG RVEILHSGQW GTICDDRWEV RVGQVVCRSL GYPGVQAVHK AAHFGQGTGP IWLNEVFCFG RESSIEECKI RQWGTRACSH SEDAGVTCTL; Positive Samples: Mouse liver, Rat liver; Cellular Location: Membrane, Single-pass type II membrane protein.
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
Specifications
CD204 | |
Polyclonal | |
Unconjugated | |
MSR1 | |
bovine scavenger receptor type II; CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; macrophage scavenger receptor type III; macrophage scavenger receptor types I and II; MRS-A; MSR; Msr1; MSR-A; phSR1; phSR2; RGD1564316; SCARA1; Scavenger receptor class A member 1; scavenger receptor class A, member 1; scavenger receptor type A; scavenger receptor type I; Scvr; SRA; SR-A; SR-AI; SR-AI/II; SR-AII | |
Rabbit | |
Affinity chromatography | |
RUO | |
20288, 4481, 498638 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ELISA, Western Blot | |
1.21 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P21757, P30204 | |
MSR1 | |
Recombinant fusion protein containing a sequence corresponding to amino acids 192-451 of human MSR1 (NP_6197291). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Your input is important to us. Please complete this form to provide feedback related to the content on this product.