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Invitrogen™ CD204 Polyclonal Antibody
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Catalog No. PIPA595991
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100 μL
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PIPA595991 100 μL
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Catalog No. PIPA595991 Supplier Invitrogen™ Supplier No. PA595991
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ANDITQSLTG KGNDSEEEMR FQEVFMEHMS NMEKRIQHIL DMEANLMDTE HFQNFSMTTD QRFNDILLQL STLFSSVQGH GNAIDEISKS LISLNTTLLD LQLNIENLNG KIQENTFKQQ EEISKLEERV YNVSAEIMAM KEEQVHLEQE IKGEVKVLNN ITNDLRLKDW EHSQTLRNIT LIQGP Positive Samples: PC-3, HUVEC, U-937, 293T, Mouse liver, Mouse testis; Cellular Location: Membrane, Single-pass type II membrane protein.

CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD204
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.30 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene MSR1
Gene Accession No. P21757, P30204
Gene Alias bovine scavenger receptor type II; CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; macrophage scavenger receptor type III; macrophage scavenger receptor types I and II; MRS-A; MSR; Msr1; MSR-A; phSR1; phSR2; RGD1564316; SCARA1; Scavenger receptor class A member 1; scavenger receptor class A, member 1; scavenger receptor type A; scavenger receptor type I; Scvr; SRA; SR-A; SR-AI; SR-AI/II; SR-AII
Gene Symbols MSR1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 90-274 of human MSR1 (NP_6197291).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20288, 4481, 498638
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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