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Invitrogen™ CD207 (Langerin) Polyclonal Antibody
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Catalog No. PIPA5121010
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100 μL
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PIPA5121010 100 μL
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Catalog No. PIPA5121010 Supplier Invitrogen™ Supplier No. PA5121010
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Description

Rabbit Polyclonal Antibody

Positive test controls include: A-549, A-431, Jurkat, Mouse lung, Rat lung, Rat liver. The target is usually found in the following locations: Membrane, Single-pass type II membrane protein. Immunogen sequence: TISDVKTNVQ LLKGRVDNIS TLDSEIKKNS DGMEAAGVQI QMVNESLGYV RSQFLKLKTS VEKANAQIQI LTRSWEEVST LNAQIPELKS DLEKASALNT KIRALQGSLE NMSKLLKRQN DILQVVSQGW K.

Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Lamgerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD207 (Langerin)
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.52 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CD207
Gene Accession No. Q8VBX4, Q9UJ71
Gene Alias CD 207 antigen; CD207; CD207 antigen; CD207 antigen, langerin; CD207 molecule; CD207 molecule, langerin; CLEC4K; C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; Langerhans cell specific c-type lectin; langerin; RGD1565913
Gene Symbols CD207
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 70-200 of human Langerin/CD207 (NP_0565324).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 246278, 502852, 50489
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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