Invitrogen™ CD21/CD35 Monoclonal Antibody (7E9)

Catalog No.	Quantity
FERMA549032	100 μg

Catalog No. FERMA549032 Supplier Invitrogen™ Supplier No. MA549032

Description

Rat Monoclonal Antibody

The monoclonal antibody 7E9 recognizes mouse complement receptors type 1 (CR1) and 2 (CR2). The monoclonal antibody 7E9 does not inhibit rosette formation between 2PK3 cells and Crd-coated SRBC indicator cells.

CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD35 encodes a membrane glycoprotein found on peripheral blood cells, glomerular podocytes, and follicular dendritic cells. The protein is a receptor for complement components C3b and C4b and regulates the activity of the complement cascade. Variation in this protein is the basis of the Knops blood group system. The two most common alleles, F and S, differ by 8 exons and are thought to be the result of an unequal crossover event. A secreted form of the protein present in plasma has been described, but its full length nature has not been determined.

Specifications

• Antigen: CD21/CD35
• Applications: Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 7E9
• Concentration: 100 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide
• Gene: Cr2
• Gene Accession No.: P19070
• Gene Alias: C3b/C4b receptor; C3-binding protein; C3DR; CD21; CD35; CD35 antigen; Complement C3d receptor; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement receptor 2; complement receptor type 1; complement receptor type 2; CR; Cr1; Cr-1; Cr2; Cr-2; CVID7; EBV receptor; Epstein-Barr virus receptor; expressed in B lymphocytes; SLEB9
• Gene Symbols: Cr2
• Host Species: Rat
• Immunogen: Purified mouse CR1 from serum.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12902
• Target Species: Mouse
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a