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Invitrogen™ CD223 Chimeric Recombinant Rabbit Monoclonal Antibody (C9B7W)
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Catalog No. PIMA548212
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200 μg
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Catalog No. Quantity
PIMA548212 200 μg
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Catalog No. PIMA548212 Supplier Invitrogen™ Supplier No. MA548212
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: This antibody is specific for an epitope in the D2 domain of murine LAG-3.

LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD223 Chimeric
Applications ELISA, Flow Cytometry, Inhibition Assays, Immunoprecipitation, Immunocytochemistry
Classification Recombinant Monoclonal
Clone C9B7W
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene LAG3
Gene Accession No. Q61790
Gene Alias Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Gene Symbols LAG3
Host Species Rabbit
Immunogen This antibody was raised by immunising Lewis rats with a murine LAG-3:Ig fusion protein.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16768
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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