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Invitrogen™ CD223 Monoclonal Antibody (333210)
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Catalog No. PIMA524062
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100 μg
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Catalog No. Quantity
PIMA524062 100 μg
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Catalog No. PIMA524062 Supplier Invitrogen™ Supplier No. MA524062
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Description

Mouse Monoclonal Antibody

In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse LAG-3 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD223
Applications Western Blot
Classification Monoclonal
Clone 333210
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene LAG3
Gene Accession No. P18627
Gene Alias Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Gene Symbols LAG3
Host Species Mouse
Immunogen Mouse myeloma cell line NS0-derived recombinant human LAG-3 Leu23-Leu450.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3902
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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