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CD23 Monoclonal Antibody (1B12), Invitrogen™

Catalog No. PIMA514054
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500 μL
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Catalog No. Quantity
PIMA514054 500 μL
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Catalog No. PIMA514054 Supplier Thermo Scientific Supplier No. MA514054

Description

Mouse Monoclonal Antibody

MA5-14054 targets CD23 in IHC (P) applications and shows reactivity with Human samples. The MA5-14054 immunogen is recombinant external domain of CD23 protein.

CD23 is a 45 kDa glycoprotein which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma. CD23 is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. Functionally, CD23 is involved in B cell growth and differentiation, and IgE production. Further, CD23 has a soluble form that is a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD23
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 1B12
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation tissue culture supernatant with 0.09% sodium azide
Gene FCER2
Gene Accession No. P06734
Gene Alias BLAST-2; CD23; CD23 antigen; CD23A; CLEC4J; C-type lectin domain family 4 member J; C-type lectin domain family 4, member J; Fc epsilon receptor II; FC epsilon RII; Fc fragment of IgE receptor II; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc receptor alpha multiple ligand receptor; Fc receptor, IgE, low affinity II, alpha polypeptide; Fcalpha muR; Fcalpha RII; Fce2; fc-epsilon-RII; FCER2; Fcer2a; FceRII; IGEBF; Immunoglobulin E-binding factor; immunoglobulin epsilon-chain; low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; low-affinity IgE receptor; Ly-42; lymphocyte IgE receptor
Gene Symbols FCER2
Host Species Mouse
Immunogen Recombinant external domain of CD23 protein
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2208
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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