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Invitrogen™ CD235a Monoclonal Antibody (YTH89.1), APC
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Catalog No. PIMA517697
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100 μg
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PIMA517697 100 μg
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Catalog No. PIMA517697 Supplier Invitrogen™ Supplier No. MA517697
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Description

Rat Monoclonal Antibody

MA5-17697 targets CD235a/Glycophorin A in FACS and WB applications and shows reactivity with Human samples. The MA5-17697 immunogen is rat monoclonal antibodies raised against human CD235a.

Glycophorin A, also known as CD235a, is a 151 amino acid sialoglycoprotein expressed on the membrane of mature erythrocytes and erythroid progenitor cells, with approximately 500,000 copies per cell. The gene for glycophorin A is located on chromosome 4 and exists in two allelic forms, M and N, which differ by two amino acids: the M group has Ser1 and Gly5, while the N group has Leu1 and Glu5. These allelic variations define the blood group M and N specificities. Glycophorin A serves multiple functions, including providing a mucin-like barrier that minimizes aggregation between red blood cells in circulation, potentially preventing cell fusion. It also acts as a receptor for certain pathogens, including Sandei virus, parvovirus, and Hsa, a Streptococcus adhesin. Recent studies suggest that exposure to toxins can lead to mutations or loss of alleles, resulting in phenotypic changes. There is ongoing research correlating genotype and phenotype with predisposition to diseases such as cancer and heart disease, highlighting the importance of glycophorin A in both health and disease. Glycophorin A is a significant marker for studying erythrocyte-related functions and pathologies, as well as its role in pathogen interactions and disease predisposition.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD235a
Applications Flow Cytometry
Classification Monoclonal
Clone YTH89.1
Concentration 0.1 mg/mL
Conjugate APC
Formulation PBS with 4-5mg/mL BSA and 0.02% sodium azide
Gene GYPA
Gene Accession No. P02724
Gene Alias AI853584; CD235; CD235a; erythroid-lineage-specific membrane sialoglycoprotein; glycophorin A; glycophorin A (MN blood group); glycophorin A (MNS blood group); glycophorin A, GPA; glycophorin Erik; glycophorin MiI; glycophorin MiV; glycophorin SAT; glycophorin Sta type C; glycophorin-A; GPA; GPErik; GPSAT; Gypa; HGNC:4702; HGpMiV; HGpMiX; HGpMiXI; HGpSta(C); HGpStaC; Mi.V glycoprotein; Mi.V glycoprotein (24 AA); MN; MN sialoglycoprotein; MNS; PAS-2; recombinant glycophorin A-B Miltenberger-DR; sialoglycoprotein alpha
Gene Symbols GYPA
Host Species Rat
Immunogen Rat monoclonal antibodies raised against human CD235a.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2993
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2b
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