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  6. Invitrogen™ CD244.2 (2B4) Monoclonal Antibody (eBio244F4), eBioscience™, Invitrogen™ 

Invitrogen™ CD244.2 (2B4) Monoclonal Antibody (eBio244F4), eBioscience™, Invitrogen™
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Catalog No. 5012998
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50-129-98 100 μg
50-129-99 500 μg
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Catalog No. 50-129-98 Supplier Invitrogen™ Supplier No. 14244182
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Description

Rat Monoclonal Antibody

Description: Mouse CD244, also known as 2B4, is a receptor belonging to the CD2 family of proteins involved in non-MHC dependent cytotoxicity. Expression is found on natural killer (NK) cells and many NKT cells and CD8+ cells. In C57BL/6 mice, two splice variants exist that differ in the length of the cytoplasmic domain. The long form functions in an inhibitory manner through signaling through SHP-2, while the short form functions in an activating manner. The ligand for CD244 is CD48 which is expressed on all hematopoietic cells. Recent data suggests that CD244 interactions with CD48, but not CD2 interaction with CD48, is essential for IL-2-driven expansion and activation of murine NK cells. Reports show CD244 expression can discriminate hematopoietic progenitors. Hematopoietic stem cells (HSC) are highly purified as CD150+CD244-CD48- cells while non-self-renewing multipotent hematopoietic progenitors (MPP) are CD244+CD150-CD48- and the most restricted progenitors are CD48+CD244+CD150-. eBio244F4 was generated against cell lines expressing CD244. It reacts with the C57BL/6 but not Balb/c due to polymorphisms present in the immunoglobulin V domain of the protein. The epitope recognized by eBio244F4 is different from that of 2B4; therefore these antibodies do not cross-block the binding to the respective epitopes. Applications Reported: This eBio244F4 antibody has been reported for use in flow cytometric analysis and immunoblotting (WB).

This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Specifications

Antigen CD244.2 (2B4)
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone eBio244F4
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Cd244
Gene Accession No. Q07763
Gene Alias 2B4; C9.1; Cd244; CD244 long isoform; CD244 natural killer cell receptor 2B4; CD244 short isoform; F730046O15Rik; Ly90; NAIL; natural killer cell receptor; natural killer cell receptor 2B4; NK cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; Nmrk; non MHC restricted killing associated; non-MHC restricted killing associated; Signaling lymphocytic activation molecule 4; SLAM family member 4; SLAMF4
Gene Symbols Cd244
Host Species Rat
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18106
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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