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CD244 Mouse anti-Human, Clone: OTI1B12, liquid, TrueMAB™

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA812270

Encompass_Preferred

Catalog No. 50-168-4492


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Description

Description

CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.
Specifications

Specifications

CD244
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q9BZW8
2B4, NAIL, NKR2B4, Nmrk, SLAMF4
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
51744
Western Blot
OTI1B12
Unconjugated
CD244
Liquid
CD244
Full length human recombit protein of human CD244 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
SDS
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Product Certifications
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