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CD25 Mouse, anti-Human, R718, Clone: 2A3, BD OptiBuild™

Catalog No. BDB752147 Shop All BD Biosciences Products
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BDB752147 50 μg
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Catalog No. BDB752147 Supplier BD Biosciences Supplier No. 752147
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Description

Mouse Monoclonal Antibody

The 2A3 monoclonal antibody specifically binds to human CD25, the low-affinity alpha subunit of the Interleukin-2 Receptor (IL- 2Rá). CD25 associates with CD122 (IL-2Râ chain) and CD132 (common ã chain or ãc) to form the high-affinity signal-transducing IL-2R complex. CD25 is expressed by subsets of thymocytes and peripheral blood lymphocytes including CD4+CD25+ regulatory T cells and memory T cells. CD25 antigen density increases on activated T cells including phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes. High levels of CD25 can be expressed by T lymphocytes from mixed lymphocyte cultures and by human T-lymphocyte leukemia virus (HTLV)-infected T-lymphocyte leukemia lines, for example, HUT-102. CD25 can also be expressed by activated B cells and macrophages. Recombinant IL-2 blocks the binding of the 2A3 antibody to PHA-activated T lymphocytes.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD25
Applications Flow Cytometry
Classification Monoclonal
Clone 2A3
Conjugate R718
Host Species Mouse
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Refrigerate Upon Arrival
Form Liquid
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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