CD26 Mouse, anti-Human, R718, Clone: L272, BD OptiBuild™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 752055

Catalog No. BDB752055

Description

The L272 monoclonal antibody specifically recognizes CD26 which is also known as Dipeptidyl peptidase IV (DPP IV), a serine protease. CD26 is a ∼120 kDa type II transmembrane glycoprotein that is encoded by DPP4 and belongs to the DPP4 activity and/or structure homologue (DASH) protein family. It is associated with the binding of the TAT transactivating protein of the HIV. CD26 and CD45 act in a costimulatory fashion on T lymphocytes. Present on peripheral blood T lymphocytes, the CD26 antigen is upregulated on phytohemagglutinin (PHA) and concanavalin A (Con A)-stimulated peripheral blood mononuclear cells (PBMCs). The CD26 antigen is found on approximately 50% of CD4 and approximately 30% of CD8 cells. It is also found on some mature thymocytes, B cells, natural killer (NK) cells, monocytes, macrophages, epithelial cells, EBV transformed B-cell lines, and hairy cell leukemia. Absolute numbers of CD4+CD26+ and CD8+CD26+ cells are reported to be lower in HIV-positive individuals. The CD26-CD4+ cell appears to be a reservoir for HIV. CD26 bright CD4 lymphocytes are CD25+ and CD45RO+ memory T lymphocytes.

Specifications

• Antigen: CD26
• Classification: Monoclonal
• Conjugate: R718
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Refrigerate Upon Arrival

• Applications: Flow Cytometry
• Clone: L272
• Host Species: Mouse
• Regulatory Status: RUO
• Target Species: Human
• Form: Liquid

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov