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Invitrogen™ CD263 (TRAIL-R3) Monoclonal Antibody (TRAIL-R3-02), PE
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Catalog No. PIMA110162
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100 μg
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Catalog No. Quantity
PIMA110162 100 μg
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Catalog No. PIMA110162 Supplier Invitrogen™ Supplier No. MA110162
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Description

Mouse Monoclonal Antibody

This antibody reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.

TRAIL-R3 (CD263) is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
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Specifications

Antigen CD263 (TRAIL-R3)
Applications Flow Cytometry
Classification Monoclonal
Clone TRAIL-R3-02
Concentration 0.1 mg/mL
Conjugate PE
Formulation PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene TNFRSF10C
Gene Accession No. O14798
Gene Alias Antagonist decoy receptor for TRAIL/Apo-2L; CD263; cytotoxic TRAIL receptor-3; DCR1; DCR1-TNFR; Decoy receptor 1; decoy TRAIL receptor without death domain; LIT; lymphocyte inhibitor of TRAIL; MGC149501; MGC149502; TNF receptor superfamily member 10c; TNF-related apoptosis-inducing ligand receptor 3; TNFRSF10C; TRAIL receptor 3; TRAIL receptor without an intracellular domain; TRAILR3; TRAIL-R3; TRID; Tumor necrosis factor receptor superfamily member 10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain; UNQ321/PRO366
Gene Symbols TNFRSF10C
Host Species Mouse
Immunogen TRAIL-R3-hIgGhc fusion protein.
Purification Method Size-exclusion chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8794
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1
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