Invitrogen™ CD263 (TRAIL-R3) Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA126368

Catalog No. PIPA126368

Description

Recommended positive controls: Human embryonic kidney cell line-293 or human T-cell line Jurkat. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TRAIL-R3 (CD263) is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

Specifications

• Antigen: CD263 (TRAIL-R3)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNFRSF10C
• Gene Alias: Antagonist decoy receptor for TRAIL/Apo-2L; CD263; cytotoxic TRAIL receptor-3; DCR1; DCR1-TNFR; Decoy receptor 1; decoy TRAIL receptor without death domain; LIT; lymphocyte inhibitor of TRAIL; MGC149501; MGC149502; TNF receptor superfamily member 10c; TNF-related apoptosis-inducing ligand receptor 3; TNFRSF10C; TRAIL receptor 3; TRAIL receptor without an intracellular domain; TRAILR3; TRAIL-R3; TRID; Tumor necrosis factor receptor superfamily member 10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain; UNQ321/PRO366
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8794
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2 mg/mL
• Formulation: 10mM potassium phosphate with 1mg/mL BSA, 140mM NaCl and 0.1% sodium azide
• Gene Accession No.: O14798
• Gene Symbols: TNFRSF10C
• Immunogen: Synthetic peptide corresponding to residues E V P Q Q T V A P Q Q Q R H S F K G E E C P A G S H R S E H T C of human TRAIL Receptor 3 (aa 33-63).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov