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  6. Invitrogen™ CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-1), eBioscience™, Invitrogen™ 

Invitrogen™ CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-1), eBioscience™, Invitrogen™

Catalog No. 14901937
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100 μg
2 mg
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14-901-937 2 mg
14-901-982 100 μg
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Catalog No. 14-901-937 Supplier Invitrogen™ Supplier No. 14901937
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Description

Mouse Monoclonal Antibody

The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration.

TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in the aorta and liver. It may also play a role in vascular cell migration and angiogenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD266 (TWEAK Receptor)
Applications Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone ITEM-1
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene TNFRSF12A
Gene Accession No. Q9NP84
Gene Alias AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14
Gene Symbols TNFRSF12A
Host Species Mouse
Purification Method Affinity chromatography
Quantity 2 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51330
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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