Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Invitrogen™ CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-1), Super Bright™ 436, eBioscience™

Mouse Monoclonal Antibody

$408.00

Specifications

Antigen CD266 (TWEAK Receptor)
Clone ITEM-1
Concentration 5 μL/Test
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Applications Flow Cytometry
View More Specs

Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
62-901-942
Encompass_Preferred
View Documents
Invitrogen™
62901942
100 Tests
Each of 1 for $408.00
Only null left
Add to Cart
 
Description

Description

Description: The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration. Applications Reported: This ITEM-1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This ITEM-1 antibody has been pre-diluted and tested by flow cytometric analysis. This may be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Super Bright 436 can be excited with the violet laser line (405 nm) and emits at 436 nm. We recommend using a 450/50 bandpass filter, or equivalent. Please make sure that your instrument is capable of detecting this fluorochrome. When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommende...

TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in the aorta and liver. It may also play a role in vascular cell migration and angiogenesis.
Specifications

Specifications

CD266 (TWEAK Receptor)
5 μL/Test
Flow Cytometry
Super Bright 436
Mouse
RUO
PBS with BSA and 0.09% sodium azide; pH 7.2
Q9NP84
51330
Primary
Affinity Chromatography
ITEM-1
4°C, store in dark, DO NOT FREEZE!
Monoclonal
Liquid
IgG1 κ
Human
TNFRSF12A
AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14
TNFRSF12A
Antibody
Videos
SDS
Documents

Documents

Product Certifications
Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.