Invitrogen™ CD267 (TACI) Polyclonal Antibody, PeproTech®, Invitrogen™

Goat Polyclonal Antibody

Supplier:  Invitrogen™ 500P166G50UG

Catalog No. 500P166G50

Description

AA Sequence of recombinant protein: SGLGRSRRGG RSRVDQEERF PQGLWTGVAM RSCPEEQYWD PLLGTCMSCK TICNHQSQRT CAAFCRSLSC RKEQGKFYDH LLRDCISCAS ICGQHPKQCA YFCENKLRSP VNLPPELRRQ RSGEVENNSD NSGRYQGLEH RGSEASPALP GLKLSADQV. Preparation: Produced from sera of goats immunized with highly pure Recombinant Human TACI. Anti-Human TACI-specific antibody was purified by affinity chromatography employing an immobilized Human TACI matrix. Sandwich ELISA: To detect Human TACI by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human TACI (500-P166GBt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human TACI. Western Blot: To detect Human TACI by Western Blot analysis this antibody can be used at a concentration of 0.1- 0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human TACI is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kappa-B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

Specifications

• Antigen: CD267 (TACI)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNFRSF13B
• Gene Alias: 1200009E08Rik; CD267; CVID; CVID2; IGAD2; NEWGENE_1595998; RYZN; TACI; TNF receptor superfamily member 13B; Tnfrsf13b; TNFRSF14B; transmembrane activator and calcium-modulating and cyclophilin ligand interactor; transmembrane activator and CAML interactor; tumor necrosis factor receptor 13B; tumor necrosis factor receptor superfamily member 13B; tumor necrosis factor receptor superfamily, member 13B
• Host Species: Goat
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23495
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: ELISA, Western Blot
• Concentration: 0.1-1.0 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: O14836
• Gene Symbols: TNFRSF13B
• Immunogen: E.coli-derived Recombinant Human TACI.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody