Invitrogen™ CD268 (BAFF Receptor) Monoclonal Antibody (8A7), PerCP-eFluor™ 710, eBioscience™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 46911742

Catalog No. 46-911-742

Description

Description: The 8A7 monoclonal antibody reacts with the human BAFF receptor, also known as B lymphocyte stimulator (BLyS protein) receptor, which is expressed on B cells. The ligand for this receptor, BAFF (B cell-activating factor of the TNF family) is a B cell survival factor and regulates CD21/35 and CD23 expression. Interaction of this ligand with its receptor causes elevated CD21/35 and CD23 expression, whereas receptor blockade has been shown to down-modulate expression. Applications Reported: This 8A7 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 8A7 antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. PerCP-eFluor 710 emits at 710 nm and is excited with the blue laser (488 nm); it can be used in place of PerCP-Cyanine5.5. We recommend using a 710/50 bandpass filter, however, the 695/40 bandpass filter is an acceptable alternative. Please make sure that your instrument is capable of detecting this fluorochrome. Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light. Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222-49)...

Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), also known as BAFFR, is a protein in humans is encoded by the TNFRSF13C gene. The BAFFR gene is mapped to chromosome 22q13. 1-q13. 31. It has got 184 amino acid transmembrane protein which is 56% identical to the mouse protein. B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. BAFF plays a crucial role in B cell development and can function through receptors other than BCMA.

Specifications

• Antigen: CD268 (BAFF Receptor)
• Classification: Monoclonal
• Concentration: 5 μL/Test
• Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q96RJ3
• Gene Symbols: TNFRSF13C
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 115650
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: 8A7
• Conjugate: PerCP-eFluor 710
• Gene: TNFRSF13C
• Gene Alias: 2010006P15Rik; B cell-activating factor receptor; BAFF receptor; BAFFR; BAFF-R; B-cell maturation defect; B-cell maturation defect 1; B-cell-activating factor receptor; Bcmd; Bcmd1; Bcmd-1; BLyS receptor 3; BR3; BROMIX; CD268; CVID4; Lvis22; prolixin; RGD1560810; TNF receptor superfamily member 13C; Tnfrsf13c; Tumor necrosis factor receptor superfamily member 13C; tumor necrosis factor receptor superfamily, member 13C
• Host Species: Mouse
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ