CD271 Mouse anti-Human, PE, Clone: C40-1457, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB560927	BD Biosciences 560927	25 Tests
BDB557196	BD Biosciences 557196	100 Tests

Description

The C40-1457 monoclonal antibody specifically binds to CD271, the nerve growth factor receptor (NGFR). CD271 is a transmembrane 75 kDa protein that has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves. It is also expressed by cells in some epithelial, mesenchymal and lymphoid tissues. NGFR is the receptor for nerve growth factor (NGF), apolypeptide that is essential for normal development of the nervous system. NGF promotes survival and differentiation of sympathetic and sensory neurons during embryological development of peripheral neurons. NGF binds to two distinctive surface receptors expressed by target cells, the p140-TrkA (NTRK1) and the p75 NGFR. High affinity binding of NGF requires that both receptor molecules be expressed. NGFR has been found on human and rat lymphocytes. A subset of lymphoid cells in the spleen, lymph nodes, and follicular dentritic cells in germinal centers of reactive lymph nodes were found to express CD271. It has been reported that NGFR interaction with its ligand, NGF, may play a role in immunoregulation. NGF may function as a B-cell growth factor.

Specifications

• Antigen: CD271
• Applications: Flow Cytometry
• Conjugate: PE
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Clone: C40-1457
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Isotype: IgG1 κ
• Purification Method: Affinity Purified
• Description: NGFR; NTR; p75NTR; p75 ICD; TNFRSF16; TNR16; LNGFR

For Research Use Only.