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CD273 Mouse, anti-Human, R718, Clone: MIH18, BD OptiBuild™

Catalog No. BDB752154 Shop All BD Biosciences Products
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BDB752154 50 μg
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Catalog No. BDB752154 Supplier BD Biosciences Supplier No. 752154
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Description

Mouse Monoclonal Antibody

The MIH18 monoclonal antibody specifically binds to CD273 which is also known as the Programmed Death Ligand 2 (PD-L2) and B7-DC. CD273 is a type 1 transmembrane glycoprotein member of the B7 family and Ig superfamily. CD273 serves as a ligand for CD279, the Programmed Death 1 (PD-1) receptor. CD273 is expressed by dendritic cells, activated monocytes, medullary thymic epithelial cells, placental trophoblasts, and myocardial endothelium. CD273 can function as a coinhibitor of T cell functions by acting through CD279. Monoclonal antibodies that block the CD273 and CD279 interaction result in enhanced T cell proliferation and cytokine production. Thus, CD273 can play an important role in regulating T cell responses. Clone MIH18 is reportedly a blocking antibody.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD273
Applications Flow Cytometry
Classification Monoclonal
Clone MIH18
Conjugate R718
Host Species Mouse
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Refrigerate Upon Arrival
Form Liquid
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