CD274, NA/LE Mouse anti-Human, Unlabeled, Clone: MIH1, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 565959

Catalog No. BDB565959

Description

The MIH1 monoclonal antibody specifically binds to CD274, which is also known as, B7 homolog 1 (B7-H1), Programmed cell death 1 ligand 1 (PDCD1 ligand, PDCD1L1, PDCD1LG1), or Programmed death ligand 1 (PD-L1, PDL1). CD274 and PD-L2 (CD273) are type I transmembrane glycoproteins that belong to the B7 family and serve as ligands for CD279 (Program Death 1/PD-1). CD274 is expressed on antigen-presenting cells including activated monocytes/macrophages and dendritic cells, as well as, activated T cells, and keratinocytes. CD274 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, and on most carcinomas. CD274 plays an important role in regulating T cell responses. The MIH1 antibody blocks CD279 binding to CD274 and can enhance the proliferation and cytokine production of activated T cells.

NA/LE

Specifications

• Antigen: CD274, NA/LE
• Clone: MIH1
• Conjugate: Unconjugated
• Gene Alias: B7-H1, B7-H, PD-L1, PDL1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1
• Immunogen: Human CD274 Transfected Cell Line
• Quantity: 500 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C.

• Classification: Monoclonal
• Concentration: 1.0mg/mL
• Formulation: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ