CD274, NA/LE Mouse anti-Human, Unlabeled, Clone: MIH1, BD

Catalog No.	Quantity
BDB565959	500 μg

Catalog No. BDB565959 Supplier BD Biosciences Supplier No. 565959

Description

Mouse Monoclonal Antibody

The MIH1 monoclonal antibody specifically binds to CD274, which is also known as, B7 homolog 1 (B7-H1), Programmed cell death 1 ligand 1 (PDCD1 ligand, PDCD1L1, PDCD1LG1), or Programmed death ligand 1 (PD-L1, PDL1). CD274 and PD-L2 (CD273) are type I transmembrane glycoproteins that belong to the B7 family and serve as ligands for CD279 (Program Death 1/PD-1). CD274 is expressed on antigen-presenting cells including activated monocytes/macrophages and dendritic cells, as well as, activated T cells, and keratinocytes. CD274 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, and on most carcinomas. CD274 plays an important role in regulating T cell responses. The MIH1 antibody blocks CD279 binding to CD274 and can enhance the proliferation and cytokine production of activated T cells.

NA/LE

Specifications

• Antigen: CD274, NA/LE
• Classification: Monoclonal
• Clone: MIH1
• Concentration: 1.0mg/mL
• Conjugate: Unconjugated
• Formulation: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
• Gene Alias: B7-H1, B7-H, PD-L1, PDL1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1
• Host Species: Mouse
• Immunogen: Human CD274 Transfected Cell Line
• Purification Method: Affinity Purified
• Quantity: 500 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C.
• Isotype: IgG1 κ