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CD274, NA/LE Mouse anti-Human, Unlabeled, Clone: MIH1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 565959

Catalog No. BDB565959


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Description

Description

The MIH1 monoclonal antibody specifically binds to CD274, which is also known as, B7 homolog 1 (B7-H1), Programmed cell death 1 ligand 1 (PDCD1 ligand, PDCD1L1, PDCD1LG1), or Programmed death ligand 1 (PD-L1, PDL1). CD274 and PD-L2 (CD273) are type I transmembrane glycoproteins that belong to the B7 family and serve as ligands for CD279 (Program Death 1/PD-1). CD274 is expressed on antigen-presenting cells including activated monocytes/macrophages and dendritic cells, as well as, activated T cells, and keratinocytes. CD274 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, and on most carcinomas. CD274 plays an important role in regulating T cell responses. The MIH1 antibody blocks CD279 binding to CD274 and can enhance the proliferation and cytokine production of activated T cells.

NA/LE
Specifications

Specifications

CD274, NA/LE
1.0mg/mL
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
B7-H1, B7-H, PD-L1, PDL1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1
Human CD274 Transfected Cell Line
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
RUO
Primary
Human
MIH1
Unconjugated
Affinity Purified
Murine
Mouse BALB/c IgG1, κ
500μg
Store undiluted at 4°C.
Monoclonal
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