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  6. Invitrogen™ CD275 (B7-H2) Monoclonal Antibody (MIH12), Functional Grade, eBioscience™, Invitrogen™ 

Invitrogen™ CD275 (B7-H2) Monoclonal Antibody (MIH12), Functional Grade, eBioscience™, Invitrogen™

Catalog No. 16588938
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16-588-938 5 mg
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Catalog No. 16-588-938 Supplier Invitrogen™ Supplier No. 16588938
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Description

Mouse Monoclonal Antibody

The MIH12 MAb reacts with human B7RP-1, also known as B7h, B7-H2, GL50 and ICOS Ligand. B7RP-1, a member of the B7 family, has a predicted molecular weight of approximately 40 kDa and belongs to the Ig superfamily. Human B7RP-1 is expressed by activated monocytes/macrophages. B7RP-1 binds to the ICOS molecule (AILIM, CRP-1) expressed by activated T cells. The interaction of ICOS/B7RP-1 plays an important role in the T cell costimulation pathway.

Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD275 (B7-H2)
Applications Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Neutralization
Classification Monoclonal
Clone MIH12
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene ICOSLG
Gene Accession No. O75144
Gene Alias AU044799; B7 homolog 2; B7 homologue 2; B7h; B7H2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP1; B7RP-1; BG071784; CD275; GI50; GL50; GL50-B; ICOS ligand; ICOSL; ICOS-L; ICOSLG; inducible T-cell costimulator ligand; inducible T-cell co-stimulator ligand; KIAA0653; LICOS; Ly115l; mKIAA0653; RGD1562791; transmembrane protein B7-H2 ICOS ligand
Gene Symbols ICOSLG
Host Species Mouse
Purification Method Affinity chromatography
Quantity 5 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23308
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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