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Invitrogen™ CD275 (B7-H2) Recombinant Rabbit Monoclonal Antibody (JE52-85)
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Catalog No. PIMA546618
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100 μL
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PIMA546618 100 μL
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Catalog No. PIMA546618 Supplier Invitrogen™ Supplier No. MA546618
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: HUVEC cell lysate, treated with TNF-alpha for 24h, Daudi cell lysate, Raji cell lysate. Subcellular Location: Cell membrane. Tissue Specificity: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells. Sequence Similarities: No Cross with Mouse and Rat.

Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD275 (B7-H2)
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone JE52-85
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene ICOSLG
Gene Accession No. O75144
Gene Alias AU044799; B7 homolog 2; B7 homologue 2; B7h; B7H2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP1; B7RP-1; BG071784; CD275; GI50; GL50; GL50-B; ICOS ligand; ICOSL; ICOS-L; ICOSLG; inducible T-cell costimulator ligand; inducible T-cell co-stimulator ligand; KIAA0653; LICOS; Ly115l; mKIAA0653; RGD1562791; transmembrane protein B7-H2 ICOS ligand
Gene Symbols ICOSLG
Host Species Rabbit
Immunogen Synthetic peptide within human CD275 aa 250-302.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23308
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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