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Invitrogen™ CD276 (B7-H3) Monoclonal Antibody (MJ18)
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Catalog No. PIMA528240
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250 μg
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Catalog No. Quantity
PIMA528240 250 μg
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Catalog No. PIMA528240 Supplier Invitrogen™ Supplier No. MA528240
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Description

Rat Monoclonal Antibody

This antibody recognizes mouse CD276, otherwise known as B7-H3, a ubiquitously expressed transmembrane glycoprotein and member of the B7 family of co-stimulatory molecules, which acts as both a positive and negative regulator of T-cell-mediated immune responses. CD276 is highly expressed in bone during embryogenesis, and can be induced on dendritic cells and monocytes by inflammatory cytokines.

CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD276 (B7-H3)
Applications Flow Cytometry
Classification Monoclonal
Clone MJ18
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene CD276
Gene Accession No. Q8VE98
Gene Alias 4Ig-B7-H3; 6030411F23Rik; AU016588; B7 homolog 3; B7h3; B7-H3; B7RP-2; CD276; CD276 antigen; CD276 molecule; CD276 molecule tv1; costimulatory molecule; PSEC0249; sB7 H3; sB7H3; sCD276; soluble B7 H3; soluble B7H3; soluble CD276; UNQ309/PRO352
Gene Symbols CD276
Host Species Rat
Immunogen Mouse IgG2a Fc-CD276 (aa 1-242).
Purification Method Protein G
Quantity 250 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 102657
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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