CD276 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-156-7547	10 μL

Catalog No. 50-156-7547 Supplier Bethyl Laboratories, Inc Supplier No. A304368AT

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat

CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.

Specifications

• Antigen: CD276
• Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation
• Classification: Polyclonal
• Concentration: 1 mg/ml
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: CD276
• Gene Accession No.: Q5ZPR3
• Gene Alias: PSEC0249; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2; B7 homolog 3; CD276 antigen; costimulatory molecule; HB7H3
• Gene Symbols: CD276
• Host Species: Rabbit
• Immunogen: Between 484 and 534
• Purification Method: Antigen affinity chromatography
• Quantity: 10 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 80381
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG