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CD279 (PD-1) Mouse, anti-Human, R718, Clone: EH12.1, BD Horizon™

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 566974

Catalog No. BDB566974


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Description

Description

The EH12.1 monoclonal antibody specifically binds to CD279 which is also known as Programmed cell death 1 (PD1). CD279 is an immunoregulatory receptor expressed on activated T cells, B cells, and myeloid cells. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. PD-L1 and PD-L2 are ligands of CD279 and members of the B7 gene family. CD279:PD-Ligands interaction inhibits T cell proliferation and cytokine secretion. Reports suggest that the B7/CTLA-4 pathway primarily attenuates, limits, and/or terminates naïve T-cell activation in secondary lymphoid organs. The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.

Specifications

Specifications

CD279 (PD-1)
EH12.1
Liquid
100 Tests
Refrigerate Upon Arrival
Monoclonal
Flow Cytometry
R718
Mouse
RUO
Primary
Human
SDS
Documents
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