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Invitrogen™ CD279 (PD-1) Recombinant Rabbit Monoclonal Antibody (BLR076G)

Catalog No. PIMA544344
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PIMA544344 10 μL
PIMA544343 100 μL
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Catalog No. PIMA544344 Supplier Invitrogen™ Supplier No. MA544344
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Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of danger signals such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD279 (PD-1)
Applications Immunohistochemistry (Paraffin)
Classification Recombinant Monoclonal
Clone BLR076G
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation BBS with 0.09% sodium azide; pH 8.2
Gene Pdcd1
Gene Accession No. Q15116
Gene Alias CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Gene Symbols Pdcd1
Host Species Rabbit
Immunogen Recombinant protein representing the extracellular domain of human PD-1 (residues 24-164).
Purification Method Purified
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5133
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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