Invitrogen™ CD2AP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596807

Catalog No. PIPA596807

Description

Positive Samples: A-431, Raji, MCF7, SW480, HL-60, Mouse kidney, Rat kidney; Cellular Location: Cell projection, Cytoplasm, cytoskeleton, ruffle Immunogen sequence: KYFSLKPEEK DEKSTLEQKP SKPAAPQVPP KKPTPPTKAS NLLRSSGTVY PKRPEKPVPP PPPIAKINGE VSSISSKFET EPVSKLKLDS EQLPLRPKSV DFDSLTVRTS KETDVVNFDD IASSENLLHL TANRPKMPGR RLPGRFNGGH SPTHSPEKIL KLPKEEDSAN LKPSELKKDT CYSPKPSVYL STPSSASKAN TTAFLTPLEI KAKVETDDVK KNSLDELRAQ IIELLCIVEA LKKDHGKELE KLRKDLEEEK TMRSNLEMEI EKLKKAVLSS.

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

Specifications

• Antigen: CD2AP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CD2AP
• Gene Alias: adapter protein CMS; AL024079; C78928; Cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2 associated protein; Cd2ap; CD2-associated protein; CMS; mesenchyme to epithelium transition protein, SH3 domains; mesenchyme-to-epithelium transition protein with SH3 domains 1; Mets1; METS-1; SH3 domain-containing adapter protein; SH3 domain-containing adaptor protein METS-1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12488, 23607, 316258
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.57 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: F1LRS8, Q9JLQ0, Q9Y5K6
• Gene Symbols: CD2AP
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 360-639 of human CD2AP (NP_0362521).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov