CD3 Monoclonal Antibody (UCHT1), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA807198

Catalog No. 50-168-1434

Description

CD3 epsilon is part of the CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in this gene are associated with T cell immunodeficiency and has been linked to Type 1 Diabetes deficiency in women.

Specifications

• Antigen: CD3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P07766
• Gene Symbols: CD3E
• Immunogen: Human infant thymocytes and lymphocytes from a patient with Sezary disease
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Western Blot
• Clone: UCHT1
• Conjugate: Unconjugated
• Gene: CD3E
• Gene Alias: IMD18; T3E; TCRE; HCD3
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 916
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid